| Tissue Specificity | Ubiquitously and weakly expressed. |
| Post Translational Modifications | Differentially phosphorylated during cell cycle. Phosphorylation may regulate association/dissociation from centrosome. During M phase of mitosis, C-terminal part is phosphorylated by NEK2, suggesting that it may trigger the dissociation from the mitotic centrosome. Dephosphorylated in vitro by the PP1 phosphatase. |
| Function | Plays an important role in centrosome cohesion during interphase. Recruits CCDC102B to the proximal ends of centrioles. Maintains centrosome cohesion by forming intercentriolar linkages. Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion. May be involved in ciliogenesis. |
| Protein Name | Centrosome-Associated Protein Cep250250 Kda Centrosomal ProteinCep250Centrosomal Nek2-Associated Protein 1C-Nap1Centrosomal Protein 2 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmPerinuclear RegionCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleCilium Basal BodyCell ProjectionCiliumPhotoreceptor Outer SegmentPhotoreceptor Inner SegmentComponent Of The Core CentrosomeIn Interphase CellsIt Specifically Associates With The Proximal Ends Of Both Mother And Daughter CentriolesAssociates With The Centrosome In Interphase CellsIn Mitotic CellsIt Dissociates From The Mitotic Spindle PolesAt The End Of Cell DivisionIt Reaccumulates At Centrosomes |
| Alternative Antibody Names | Anti-Centrosome-Associated Protein Cep250 antibodyAnti-250 Kda Centrosomal Protein antibodyAnti-Cep250 antibodyAnti-Centrosomal Nek2-Associated Protein 1 antibodyAnti-C-Nap1 antibodyAnti-Centrosomal Protein 2 antibodyAnti-CEP250 antibodyAnti-CEP2 antibodyAnti-CNAP1 antibody |
Information sourced from Uniprot.org
