| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CENPB (C-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CENPB |
| Gene ID: |
1059 |
| Uniprot ID: |
CENPB_HUMAN |
| Immunogen Region: |
C-Term |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human CENPB (NP_001801.1). |
| Immunogen Sequence: |
TLHFLEGGEDSDSDSEEEDD EEEDDEDEDDDDDEEDGDEV PVPSFGEAMAYFAMVKRYLT SFPIDDRVQSHILHLEHDLV HVTRKNHARQAGVRGLGHQS |
| Post Translational Modifications | Poly-ADP-ribosylated by PARP1. N-terminally methylated by METTL11A/NTM1. Alpha-N-methylation is stimulated in response to extracellular stimuli, including increased cell density and heat shock, and seems to facilitate binding to CENP-B boxes. Chromatin-bound CENP-B is primarily trimethylated. |
| Function | Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable). |
| Protein Name | Major Centromere Autoantigen BCentromere Protein BCenp-B |
| Cellular Localisation | NucleusChromosomeCentromere |
| Alternative Antibody Names | Anti-Major Centromere Autoantigen B antibodyAnti-Centromere Protein B antibodyAnti-Cenp-B antibodyAnti-CENPB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
