| Function | Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis. |
| Protein Name | Histone H3-Like Centromeric Protein ACentromere Autoantigen ACentromere Protein ACenp-A |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-606279Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereLocalizes Exclusively To Sites Of Kinetochore Assembly In CentromeresOccupies A Compact Domain At The Inner Kinetochore Plate Stretching Across 2 Thirds Of The Length Of The Constriction But Encompassing Only One Third Of The Constriction Width And HeightPhosphorylation At Ser-68 During Early Mitosis Abolishes Association With Chromatin And Centromeres And Results In Dispersed Nuclear Location |
| Alternative Antibody Names | Anti-Histone H3-Like Centromeric Protein A antibodyAnti-Centromere Autoantigen A antibodyAnti-Centromere Protein A antibodyAnti-Cenp-A antibodyAnti-CENPA antibody |
Information sourced from Uniprot.org
