Anti-CDX2 antibody (1-50) {FITC} (STJ500498)

SKU:
STJ500498-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CDX2 (1-50) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.65 µg/µl
Dilution Range: WB: 1:500
DB: 1:4, 000
ELISA: 1:4, 000
IP: 1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: CDX2
Gene ID: 1045
Uniprot ID: CDX2_HUMAN
Immunogen Region: 1-50
Immunogen: N-epitope synthetic peptide taken within amino acid region 1-50 on human CDX2 protein.
Tissue Specificity Detected in small intestine, colon and pancreas.
Post Translational Modifications Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation.
Function Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2. Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA.
Protein Name Homeobox Protein Cdx-2
Cdx-3
Caudal-Type Homeobox Protein 2
Database Links Reactome: R-HSA-381771
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Homeobox Protein Cdx-2 antibody
Anti-Cdx-3 antibody
Anti-Caudal-Type Homeobox Protein 2 antibody
Anti-CDX2 antibody
Anti-CDX3 antibody

Information sourced from Uniprot.org

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