• Immunohistochemistry analysis of CDX2 in paraffin-embedded mouse colon tissue using CDX2 Rabbit polyclonal antibody (STJ11103868) at a dilution of 1:2000 (40x lens). High pressure antigen retrieval was performed with 0. 01 M Tris-EDTA buffer (pH 9. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of CDX2 in paraffin-embedded human colon tissue using CDX2 Rabbit polyclonal antibody (STJ11103868) at a dilution of 1:2000 (40x lens). High pressure antigen retrieval was performed with 0. 01 M Tris-EDTA buffer (pH 9. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of CDX2 in paraffin-embedded rat colon tissue using CDX2 Rabbit polyclonal antibody (STJ11103868) at a dilution of 1:2000 (40x lens). High pressure antigen retrieval was performed with 0. 01 M Tris-EDTA buffer (pH 9. 0) prior to immunohistochemistry staining.

Anti-CDX2 antibody (1-180) (STJ11103868)

SKU:
STJ11103868

£112.50 - £522.50
Current Stock:
Host: Rabbit
Applications: IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Homeobox Protein Cdx-2 (1-180) is suitable for use in Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:1000-1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CDX2
Gene ID: 1045
Uniprot ID: CDX2_HUMAN
Immunogen Region: 1-180
Immunogen: Recombinant Protein corresponding to a sequence within amino acids 1-180 of human CDX2 (NP_001256.3).
Immunogen Sequence: MYVSYLLDKDVSMYPSSVRH SGGLNLAPQNFVSPPQYPDY GGYHVAAAAAAAANLDSAQS PGPSWPAAYGAPLREDWNGY APGGAAAAANAVAHGLNGGS PAAAMGYSSPADYHPHHHPH HHPHHPAAAPSCASGLLQTL NPGPPGPAATAAAEQLSPGG QRRNLCEWMRKPAQQSLGSQ
Tissue Specificity Detected in small intestine, colon and pancreas.
Post Translational Modifications Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation.
Function Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2. Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA.
Protein Name Homeobox Protein Cdx-2
Cdx-3
Caudal-Type Homeobox Protein 2
Database Links Reactome: R-HSA-381771
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Homeobox Protein Cdx-2 antibody
Anti-Cdx-3 antibody
Anti-Caudal-Type Homeobox Protein 2 antibody
Anti-CDX2 antibody
Anti-CDX3 antibody

Information sourced from Uniprot.org

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