| Short Description : | Rabbit polyclonal CDX1 (136-265) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDX1 |
| Gene ID: | 1044 |
| Uniprot ID: | CDX1_HUMAN |
| Immunogen Region: | 136-265 |
| Immunogen Sequence: | MRRSVAAGGGGGSGKTRTKD KYRVVYTDHQRLELEKEFHY SRYITIRRKSELAANLGLTE RQVKIWFQNRRAKERKVNKK KQQQQQPPQPPMAHDITATP AGPSLGGLCPSNTSLLATSS PMPVKEEFLP |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 136-265 of human CDX1 (NP_001795.2). |
| Tissue Specificity | Intestinal epithelium. |
| Function | Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA. |
| Protein Name | Homeobox Protein Cdx-1Caudal-Type Homeobox Protein 1 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Cdx-1 antibodyAnti-Caudal-Type Homeobox Protein 1 antibodyAnti-CDX1 antibody |
Information sourced from Uniprot.org
