| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDKN2B |
| Gene ID: | 1030 |
| Uniprot ID: | CDN2B_HUMAN |
| Immunogen Region: | 1-138 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-138 of human CDKN2B (NP_004927.2). |
| Immunogen Sequence: | MREENKGMPSGGGSDEGLAS AAARGLVEKVRQLLEAGADP NGVNRFGRRAIQVMMMGSAR VAELLLLHGAEPNCADPATL TRPVHDAAREGFLDTLVVLH RAGARLDVRDAWGRLPVDLA EERGHRDVAGYLRTATGD |
| Tissue Specificity | Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines. |
| Function | Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. |
| Protein Name | Cyclin-Dependent Kinase 4 Inhibitor BMultiple Tumor Suppressor 2Mts-2P14-Ink4bP15-Ink4bP15ink4b |
| Database Links | Reactome: R-HSA-2173796Reactome: R-HSA-2559580Reactome: R-HSA-2559582Reactome: R-HSA-2559585Reactome: R-HSA-69231 |
| Cellular Localisation | CytoplasmAlso Found In The Nucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 4 Inhibitor B antibodyAnti-Multiple Tumor Suppressor 2 antibodyAnti-Mts-2 antibodyAnti-P14-Ink4b antibodyAnti-P15-Ink4b antibodyAnti-P15ink4b antibodyAnti-CDKN2B antibodyAnti-MTS2 antibody |
Information sourced from Uniprot.org