| Short Description : | Rabbit monoclonal anti-CDKN2A/p16INK4a for use in WB, ICC, IF and IP in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ICC/IF/IP |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | R07-2K1 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.3 mg/mL |
| Purification: | Affinity Purified |
| Dilution Range: | WB 1:500-1:1000IF 1:50-1:200IP 1:20 |
| Formulation: | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | Cdkn2a |
| Gene ID: | 12578 |
| Uniprot ID: | CDN2A_MOUSE |
| Immunogen: | Recombinant protein of mouse CDKN2A/p16INK4a |
| Post Translational Modifications | Phosphorylation seems to increase interaction with CDK4. |
| Function | Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. |
| Protein Name | Cyclin-Dependent Kinase Inhibitor 2aCyclin-Dependent Kinase 4 Inhibitor ACdk4iP16-Ink4aP16-Ink4 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase Inhibitor 2a antibodyAnti-Cyclin-Dependent Kinase 4 Inhibitor A antibodyAnti-Cdk4i antibodyAnti-P16-Ink4a antibodyAnti-P16-Ink4 antibodyAnti-Cdkn2a antibodyAnti-P16ink4a antibody |
Information sourced from Uniprot.org
