| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CDK5RAP3 (1-300) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CDK5RAP3 |
| Gene ID: |
80279 |
| Uniprot ID: |
CK5P3_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CDK5RAP3 (NP_788276.1). |
| Immunogen Sequence: |
MEDHQHVPIDIQTSKLLDWL VDRRHCSLKWQSLVLTIREK INAAIQDMPESEEIAQLLSG SYIHYFHCLRILDLLKGTEA STKNIFGRYSSQRMKDWQEI IALYEKDNTYLVELSSLLVR NVNYEIPSLKKQIAKCQQLQ QEYSRKEEECQAGAAEMREQ FYHSCKQYGITGENVRGELL ALVKDLPSQLAEIGAAAQQS LGEAIDVYQASVGFVCESPT EQVLPMLRFVQKRGNSTVY |
| Tissue Specificity | Ubiquitously expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta. |
| Post Translational Modifications | May be phosphorylated by CDK5. Ubiquitinated. Probably triggers proteasomal degradation and is negatively regulated by UFL1. May be ufmylated. Cleaved by caspases early during apoptosis, the resulting peptides may play a role in rupture of the nuclear envelope. |
| Function | Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May also play a role in the rupture of the nuclear envelope during apoptosis. May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1. Required for liver development. (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry. |
| Protein Name | Cdk5 Regulatory Subunit-Associated Protein 3Cdk5 Activator-Binding Protein C53Lxxll/Leucine-Zipper-Containing Arf-Binding ProteinProtein Hsf-27 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeColocalizes And Associates With Microtubules |
| Alternative Antibody Names | Anti-Cdk5 Regulatory Subunit-Associated Protein 3 antibodyAnti-Cdk5 Activator-Binding Protein C53 antibodyAnti-Lxxll/Leucine-Zipper-Containing Arf-Binding Protein antibodyAnti-Protein Hsf-27 antibodyAnti-CDK5RAP3 antibodyAnti-IC53 antibodyAnti-LZAP antibodyAnti-MSTP016 antibodyAnti-OK antibodyAnti-SW-cl.114 antibodyAnti-PP1553 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
