| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Mitochondrial tRNA methylthiotransferase CDK5RAP1adenosine37 methylthiotransferase (251-300 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300 ELISA 1:20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDK5RAP1 |
| Gene ID: | 51654 |
| Uniprot ID: | CK5P1_HUMAN |
| Immunogen Region: | 251-300 aa |
| Specificity: | CDK5 Activator-binding C42 Polyclonal Antibody detects endogenous levels of CDK5 Activator-binding C42 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CDK5RAP1 at the amino acid range 251-300 |
| Function | Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp). Essential for efficient and highly accurate protein translation by the ribosome. Specifically inhibits CDK5 activation by CDK5R1. Essential for efficient mitochondrial protein synthesis and respiratory chain.shows pathological consequences in mitochondrial disease. |
| Protein Name | Mitochondrial Trna Methylthiotransferase Cdk5rap1 Cdk5 Activator-Binding Protein C42 Cdk5 Regulatory Subunit-Associated Protein 1 Mt-Trna-2-Methylthio-N6-Dimethylallyladenosine Synthase Mt-Trna-N6-(Dimethylallyladenosine(37 Methylthiotransferase |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Mitochondrial Trna Methylthiotransferase Cdk5rap1 antibody Anti-Cdk5 Activator-Binding Protein C42 antibody Anti-Cdk5 Regulatory Subunit-Associated Protein 1 antibody Anti-Mt-Trna-2-Methylthio-N6-Dimethylallyladenosine Synthase antibody Anti-Mt-Trna-N6-(Dimethylallyladenosine(37 Methylthiotransferase antibody Anti-CDK5RAP1 antibody Anti-C20orf34 antibody Anti-CGI-05 antibody Anti-HSPC167 antibody |
Information sourced from Uniprot.org