| Function | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. |
| Protein Name | Cyclin-Dependent Kinase 13Cdc2-Related Protein Kinase 5Cell Division Cycle 2-Like Protein Kinase 5Cell Division Protein Kinase 13Hcdk13Cholinesterase-Related Cell Division Controller |
| Database Links | Reactome: R-HSA-6796648Reactome: R-HSA-6798695 |
| Cellular Localisation | Nucleus Speckle |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 13 antibodyAnti-Cdc2-Related Protein Kinase 5 antibodyAnti-Cell Division Cycle 2-Like Protein Kinase 5 antibodyAnti-Cell Division Protein Kinase 13 antibodyAnti-Hcdk13 antibodyAnti-Cholinesterase-Related Cell Division Controller antibodyAnti-CDK13 antibodyAnti-CDC2L antibodyAnti-CDC2L5 antibodyAnti-CHED antibodyAnti-KIAA1791 antibody |
Information sourced from Uniprot.org
