| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CDK13 (620-900) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CDK13 |
| Gene ID: |
8621 |
| Uniprot ID: |
CDK13_HUMAN |
| Immunogen Region: |
620-900 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 620-900 of human CDK13 (NP_003709.3). |
| Immunogen Sequence: |
KEADSLRGNISVKAVKKEVE KKLRCLLADLPLPPELPGGD DLSKSPEEKKTATQLHSKRR PKICGPRYGETKEKDIDWGK RCVDKFDIIGIIGEGTYGQV YKARDKDTGEMVALKKVRLD NEKEGFPITAIREIKILRQL THQSIINMKEIVTDKEDALD FKKDKGAFYLVFEYMDHDLM GLLESGLVHFNENHIKSFMR QLMEGLDYCHKKNFLHRDIK CSNILLNNRGQIKLADFGL |
| Tissue Specificity | Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors. |
| Function | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. |
| Protein Name | Cyclin-Dependent Kinase 13Cdc2-Related Protein Kinase 5Cell Division Cycle 2-Like Protein Kinase 5Cell Division Protein Kinase 13Hcdk13Cholinesterase-Related Cell Division Controller |
| Database Links | Reactome: R-HSA-6796648Reactome: R-HSA-6798695 |
| Cellular Localisation | Nucleus Speckle |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 13 antibodyAnti-Cdc2-Related Protein Kinase 5 antibodyAnti-Cell Division Cycle 2-Like Protein Kinase 5 antibodyAnti-Cell Division Protein Kinase 13 antibodyAnti-Hcdk13 antibodyAnti-Cholinesterase-Related Cell Division Controller antibodyAnti-CDK13 antibodyAnti-CDC2L antibodyAnti-CDC2L5 antibodyAnti-CHED antibodyAnti-KIAA1791 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
