| Host: | Mouse |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Cadherin-5 is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Monoclonal |
| Conjugation: | Unconjugated |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-300 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDH5 |
| Gene ID: | 1003 |
| Uniprot ID: | CADH5_HUMAN |
| Specificity: | The antibody detects endogenous VE-Cadherin protein |
| Immunogen: | Synthetic Peptide of VE-Cadherin |
| Post Translational Modifications | Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. O-glycosylated. |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Plays a role in coupling actin fibers to cell junctions in endothelial cells, via acting as a cell junctional complex anchor for AMOTL2 and MAGI1. Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. |
| Protein Name | Cadherin-5 7b4 Antigen Vascular Endothelial Cadherin Ve-Cadherin Cd Antigen Cd144 |
| Database Links | Reactome: R-HSA-418990 Reactome: R-HSA-5218920 |
| Cellular Localisation | Cell Junction Adherens Junction Cell Membrane Single-Pass Type I Membrane Protein Cytoplasm Found At Cell-Cell Boundaries And Probably At Cell-Matrix Boundaries Krit1 And Cdh5 Reciprocally Regulate Their Localization To Endothelial Cell-Cell Junctions |
| Alternative Antibody Names | Anti-Cadherin-5 antibody Anti-7b4 Antigen antibody Anti-Vascular Endothelial Cadherin antibody Anti-Ve-Cadherin antibody Anti-Cd Antigen Cd144 antibody Anti-CDH5 antibody |
Information sourced from Uniprot.org