| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDH11 |
| Gene ID: | 1009 |
| Uniprot ID: | CAD11_HUMAN |
| Immunogen Region: | 120-796 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human CDH11 (NP_001788.2). |
| Immunogen Sequence: | ERAQYTLMAQAVDRDTNRPL EPPSEFIVKVQDINDNPPEF LHETYHANVPERSNVGTSVI QVTASDADDPTYGNSAKLVY SILEGQPYFSVEAQTGIIRT ALPNMDREAKEEYHVVIQAK DMGGHMGGLSGTTKVTITLT DVNDNPPKFPQSVYQMSVSE AAVPGEEVGRVKAKDPDIGE NGLVTYNIVDGDGMESFEIT TDYETQEGVIKLKKPVDFET KRAYSLKVEAANVHIDPKF |
| Tissue Specificity | Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. In the embryo from 67 to 72 days of gestation, detected at high levels in facial mesenchyme including the central palatal mesenchyme, dental mesenchyme, the eye and optic muscle, and the tongue (at protein level). |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly. Involved in the regulation of cell migration. |
| Protein Name | Cadherin-11 Osf-4 Osteoblast Cadherin Ob-Cadherin |
| Database Links | Reactome: R-HSA-418990 Reactome: R-HSA-9759811 Reactome: R-HSA-9762292 Reactome: R-HSA-9833576 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cadherin-11 antibody Anti-Osf-4 antibody Anti-Osteoblast Cadherin antibody Anti-Ob-Cadherin antibody Anti-CDH11 antibody |
Information sourced from Uniprot.org