| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cell division cycle-associated protein 7 (141-190 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDCA7 |
| Gene ID: | 83879 |
| Uniprot ID: | CDCA7_HUMAN |
| Immunogen Region: | 141-190 aa |
| Specificity: | CdcA7 Polyclonal Antibody detects endogenous levels of CdcA7 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CDCA7 at the amino acid range 141-190 |
| Post Translational Modifications | Phosphorylation at Thr-163 promotes interaction with YWHAE and YWHAZ, dissociation from MYC and sequestration in the cytoplasm. In vitro, phosphorylated at Thr-163 by AKT. |
| Function | Participates in MYC-mediated cell transformation and apoptosis.induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator. |
| Protein Name | Cell Division Cycle-Associated Protein 7Protein Jpo1 |
| Cellular Localisation | NucleusCytoplasmPredominantly Nuclear With Some Expression Also Seen In The CytoplasmPredominantly Cytoplasmic When Phosphorylated At Thr-163 |
| Alternative Antibody Names | Anti-Cell Division Cycle-Associated Protein 7 antibodyAnti-Protein Jpo1 antibodyAnti-CDCA7 antibodyAnti-JPO1 antibody |
Information sourced from Uniprot.org