| Post Translational Modifications | Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPL by CDCA5. Ubiquitinated by the APC/C complex in G1, leading to its degradation. |
| Function | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. |
| Protein Name | SororinCell Division Cycle-Associated Protein 5P35 |
| Database Links | Reactome: R-HSA-2467813Reactome: R-HSA-2468052Reactome: R-HSA-2500257 |
| Cellular Localisation | NucleusChromosomeCytoplasmAssociates With Nuclear Chromatin From S Phase Until Metaphase And Is Released In The Cytoplasm Upon Nuclear Envelope Breakdown |
| Alternative Antibody Names | Anti-Sororin antibodyAnti-Cell Division Cycle-Associated Protein 5 antibodyAnti-P35 antibodyAnti-CDCA5 antibody |
Information sourced from Uniprot.org
