| Tissue Specificity | Expressed in all tissues examined, with high levels in heart, brain, placenta and lung. |
| Post Translational Modifications | Proteolytically cleaved by caspases upon apoptosis induction. |
| Function | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. |
| Protein Name | Serine/Threonine-Protein Kinase Mrck BetaCdc42-Binding Protein Kinase BetaCdc42bp-BetaDmpk-Like BetaMyotonic Dystrophy Kinase-Related Cdc42-Binding Kinase BetaMrck BetaMyotonic Dystrophy Protein Kinase-Like Beta |
| Database Links | Reactome: R-HSA-9013148Reactome: R-HSA-9013406Reactome: R-HSA-9013409 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideCell JunctionCell ProjectionLamellipodiumDisplays A Dispersed Punctate Distribution And Concentrates Along The Cell PeripheryEspecially At The Leading Edge And Cell-Cell JunctionThis Concentration Is Ph-Domain DependentDetected At The Leading Edge Of Migrating CellsLocalization At The Leading Edge Of Migrating Cells Requires Interaction With Catalytically Active Cdc42Localizes In The Lamellipodium In A Fam89b/Lrap25-Dependent Manner |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Mrck Beta antibodyAnti-Cdc42-Binding Protein Kinase Beta antibodyAnti-Cdc42bp-Beta antibodyAnti-Dmpk-Like Beta antibodyAnti-Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Beta antibodyAnti-Mrck Beta antibodyAnti-Myotonic Dystrophy Protein Kinase-Like Beta antibodyAnti-CDC42BPB antibodyAnti-KIAA1124 antibody |
Information sourced from Uniprot.org
