Anti-Cd8a antibody [53-6.7] {EV450} (STJA0003908)

SKU:
STJA0003908

€128.13 - €176.88
Current Stock:
Host: Rat
Applications: FC
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-T-cell surface glycoprotein CD8 alpha chain is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: 53-6.7
Conjugation: EV450
Isotype: IgG2ak
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: Cd8a
Gene ID: 12525
Uniprot ID: CD8A_MOUSE
Post Translational Modifications Palmitoylated, but association with CD8B seems to be more important for the enrichment of CdD8A in lipid rafts. Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.
Function Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Protein Name T-Cell Surface Glycoprotein Cd8 Alpha Chain
T-Cell Surface Glycoprotein Lyt-2
Cd Antigen Cd8a
Database Links Reactome: R-MMU-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cd8a Localizes To Lipid Rafts Only When Associated With Its Partner Cd8b
Alternative Antibody Names Anti-T-Cell Surface Glycoprotein Cd8 Alpha Chain antibody
Anti-T-Cell Surface Glycoprotein Lyt-2 antibody
Anti-Cd Antigen Cd8a antibody
Anti-Cd8a antibody
Anti-Lyt-2 antibody
Anti-Lyt2 antibody

Information sourced from Uniprot.org

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