Anti-CD83 antibody (20-143) [S4824RM] (STJ11104824)

Name: Anti-CD83 antibody (20-143) [S4824RM] (STJ11104824)
SKU: STJ11104824
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11104824

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Short Description	Rabbit monoclonal Cd83 antigen (20-143) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	S4824RM
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:1000-1:5000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	CD83
Gene ID	9308
Uniprot ID	CD83_HUMAN
Immunogen Region	20-143
Immunogen Sequence	TPEVKVACSEDVDLPCTAPW DPQVPYTVSWVKLLEGGEER METPQEDHLRGQHYHQKGQN GSFDAPNERPYSLKIRNTTS CNSGTYRCTLQDPDGQRNLS GKVILRVTGCPAQRKEETFK KYRA
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 20-143 of human CD83 (NP_004224.1).

Tissue Specificity	Expressed by activated lymphocytes, Langerhans cells and activatd dendritic cells.
Post Translational Modifications	Glycosylated when expressed on activated dendritic cells.
Function	Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation. In addition, acts as an important modulator of protective responses against acute infections.
Protein Name	Cd83 Antigen Hcd83 B-Cell Activation Protein Cell Surface Protein Hb15 Cd Antigen Cd83
Database Links
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-Cd83 Antigen antibody Anti-Hcd83 antibody Anti-B-Cell Activation Protein antibody Anti-Cell Surface Protein Hb15 antibody Anti-Cd Antigen Cd83 antibody Anti-CD83 antibody

Information sourced from Uniprot.org