| Host: |
Rabbit |
| Applications: |
WB/IHC-P/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:100-1:500IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CD82 |
| Gene ID: |
3732 |
| Uniprot ID: |
CD82_HUMAN |
| Immunogen Region: |
150-250 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human CD82 (NP_002222.1). |
| Immunogen Sequence: |
CGWVSFYNWTDNAELMNRPE VTYPCSCEVKGEEDNSLSVR KGFCEAPGNRTQSGNHPEDW PVYQEGCMEKVQAWLQENLG IILGVGVGVAIIELLGMVLS I |
| Tissue Specificity | Lymphoid specific. |
| Post Translational Modifications | Palmitoylated. Palmitoylation contributes to oligomerization and surface expression. |
| Function | Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Acts as a attenuator of EGF signaling, facilitating ligand-induced endocytosis of the receptor and its subsequent desensitization. Mechanistically, modulates ligand-induced ubiquitination and trafficking of EGFR via E3 ligase CBL phosphorylation by PKC. Increases cell-matrix adhesion by regulating the membrane organization of integrin alpha4/ITA4. Modulates adhesion and suppresses cell migration through other integrins such as the alpha6/ITGA6 and beta1/ITGB1. Decreases cell-associated plasminogen activation by interfering with the interaction between urokinase-type plasminogen activator/PLAU and its receptor PLAUR. Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. Plays a role in TLR9 trafficking to acidified CpG-containing compartments by controlling interaction between TLR9 and VAMP3 and subsequent myddosome assembly. Inhibits LPS-induced inflammatory response by preventing binding of LPS to TLR4 on the cell surface. Plays a role in the activation of macrophages into anti-inflammatory phenotypes. Independently of Toll-like receptor (TLR) signaling, is recruited to pathogen-containing phagosomes prior to fusion with lysosomes and thereby participates in antigen presentation. Acts also to control angiogenesis and switch angiogenic milieu to quiescent state by binding and sequestering VEGFA and PDGFB to inhibit the signaling they trigger via their respective cell surface receptor. |
| Protein Name | Cd82 AntigenC33 AntigenIa4Inducible Membrane Protein R2Metastasis Suppressor Kangai-1Suppressor Of Tumorigenicity 6 ProteinTetraspanin-27Tspan-27Cd Antigen Cd82 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic VesiclePhagosome |
| Alternative Antibody Names | Anti-Cd82 Antigen antibodyAnti-C33 Antigen antibodyAnti-Ia4 antibodyAnti-Inducible Membrane Protein R2 antibodyAnti-Metastasis Suppressor Kangai-1 antibodyAnti-Suppressor Of Tumorigenicity 6 Protein antibodyAnti-Tetraspanin-27 antibodyAnti-Tspan-27 antibodyAnti-Cd Antigen Cd82 antibodyAnti-CD82 antibodyAnti-KAI1 antibodyAnti-SAR2 antibodyAnti-ST6 antibodyAnti-TSPAN27 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
