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![Anti-Cd80 antibody [16-10A1] {FITC} (STJA0001230)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/147014/292715/STJA0001230_1__95187.1631206598.jpg?c=1 "Anti-Cd80 antibody [16-10A1] {FITC} (STJA0001230)")
Anti-Cd80 antibody [16-10A1] {FITC} (STJA0001230)
SPECIFICATIONS
ClonalityMonoclonal
HostArmenian Hamster
ConjugationFITC
IsotypeIgG
General Information
| Short Description | Armenian Hamster monoclonal anti-T-lymphocyte activation antigen CD80 for use in FC in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Armenian Hamster |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 16-10A1 |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 5 Mu L/Test |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | Cd80 |
| Gene ID | 12519 |
| Uniprot ID | CD80_MOUSE |
Additional Info
| Tissue Specificity | Expressed on activated B-cells, gamma interferon stimulated monocytes and non-circulating B-cell malignancies. |
| Function | Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells. In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway. Acts also as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses. Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses. |
| Protein Name | T-Lymphocyte Activation Antigen Cd80Activation B7-1 AntigenB7Cd Antigen Cd80 |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-389356Reactome: -MMU-389357Reactome: -MMU-389359Reactome: -MMU-389513Reactome: -MMU-6811558 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Lymphocyte Activation Antigen Cd80 antibodyAnti-Activation B7-1 Antigen antibodyAnti-B7 antibodyAnti-Cd Antigen Cd80 antibodyAnti-Cd80 antibodyAnti-B7 antibody |
Information sourced from Uniprot.org