| Tissue Specificity | Isoform Long: Expressed in thymus and lymph noodes. Expressed by antigen-presenting cells (APCs). Isoform Short: Expressed in thymus and lymph noodes. |
| Function | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. Isoform Long: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Class-II-associated invariant chain peptide: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. |
| Protein Name | H-2 Class Ii Histocompatibility Antigen Gamma ChainIa Antigen-Associated Invariant ChainIiIi ChainMhc Class Ii-Associated Invariant ChainCd Antigen Cd74 Cleaved Into - Class-Ii-Associated Invariant Chain PeptideClip |
| Database Links | Reactome: R-MMU-202733Reactome: -MMU-2132295 |
| Cellular Localisation | Isoform Long: Late EndosomeLysosomeCell MembraneSingle-Pass Type Ii Membrane ProteinEndoplasmic Reticulum MembraneGolgi ApparatusTrans-Golgi NetworkEndosomeSecretedTransits Through A Number Of Intracellular Compartments In The Endocytic PathwayIt Can Either Undergo Proteolysis Or Reach The Cell Membrane |
| Alternative Antibody Names | Anti-H-2 Class Ii Histocompatibility Antigen Gamma Chain antibodyAnti-Ia Antigen-Associated Invariant Chain antibodyAnti-Ii antibodyAnti-Ii Chain antibodyAnti-Mhc Class Ii-Associated Invariant Chain antibodyAnti-Cd Antigen Cd74 Cleaved Into - Class-Ii-Associated Invariant Chain Peptide antibodyAnti-Clip antibodyAnti-Cd74 antibodyAnti-Ii antibody |
Information sourced from Uniprot.org
