| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CD74 (56-215) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Cd74 |
| Gene ID: |
16149 |
| Uniprot ID: |
HG2A_MOUSE |
| Immunogen Region: |
56-215 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 56-215 of mouse CD74 (NP_034675.1). |
| Immunogen Sequence: |
QQQGRLDKLTITSQNLQLES LRMKLPKSAKPVSQMRMATP LLMRPMSMDNMLLGPVKNVT KYGNMTQDHVMHLLTRSGPL EYPQLKGTFPENLKHLKNSM DGVNWKIFESWMKQWLLFEM SKNSLEEKKPTEAPPKEPLD MEDLSSGLGVTRQELGQVTL |
| Tissue Specificity | Isoform Long: Expressed in thymus and lymph noodes. Expressed by antigen-presenting cells (APCs). Isoform Short: Expressed in thymus and lymph noodes. |
| Function | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. Isoform Long: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Class-II-associated invariant chain peptide: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. |
| Protein Name | H-2 Class Ii Histocompatibility Antigen Gamma ChainIa Antigen-Associated Invariant ChainIiIi ChainMhc Class Ii-Associated Invariant ChainCd Antigen Cd74 Cleaved Into - Class-Ii-Associated Invariant Chain PeptideClip |
| Database Links | Reactome: R-MMU-202733Reactome: -MMU-2132295 |
| Cellular Localisation | Isoform Long: Late EndosomeLysosomeCell MembraneSingle-Pass Type Ii Membrane ProteinEndoplasmic Reticulum MembraneGolgi ApparatusTrans-Golgi NetworkEndosomeSecretedTransits Through A Number Of Intracellular Compartments In The Endocytic PathwayIt Can Either Undergo Proteolysis Or Reach The Cell Membrane |
| Alternative Antibody Names | Anti-H-2 Class Ii Histocompatibility Antigen Gamma Chain antibodyAnti-Ia Antigen-Associated Invariant Chain antibodyAnti-Ii antibodyAnti-Ii Chain antibodyAnti-Mhc Class Ii-Associated Invariant Chain antibodyAnti-Cd Antigen Cd74 Cleaved Into - Class-Ii-Associated Invariant Chain Peptide antibodyAnti-Clip antibodyAnti-Cd74 antibodyAnti-Ii antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
