| Host: |
Mouse |
| Applications: |
IHC-F/FC/IP/IHC-P/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-CD72 is suitable for use in Immunohistochemistry, Flow Cytometry, Immunoprecipitation, Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
Bu40 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2a |
| Formulation: |
PBS with <0.1% sodium azide |
| Purification: |
Purified |
| Concentration: |
1 mg/mL |
| Storage Instruction: |
Store aliquots at-20°C, and thawed aliquots at 2-8°C. |
| Tissue Specificity | Pre-B-cells and B-cells but not terminally differentiated plasma cells. |
| Post Translational Modifications | Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1. |
| Function | Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Acts also as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis. |
| Protein Name | B-Cell Differentiation Antigen Cd72Lyb-2Cd Antigen Cd72 |
| Database Links | Reactome: R-HSA-416700 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-B-Cell Differentiation Antigen Cd72 antibodyAnti-Lyb-2 antibodyAnti-Cd Antigen Cd72 antibodyAnti-CD72 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
