| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-CD63 is suitable for use in Flow Cytometry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | MEM-259 |
| Conjugation: | PE |
| Isotype: | IgG1 |
| Formulation: | Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Gene Symbol: | CD63 |
| Gene ID: | 967 |
| Uniprot ID: | CD63_HUMAN |
| Immunogen: | HPB-ALL T cell line |
| Tissue Specificity | Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages. |
| Post Translational Modifications | Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). |
| Function | Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. |
| Protein Name | Cd63 Antigen Granulophysin Lysosomal-Associated Membrane Protein 3 Lamp-3 Lysosome Integral Membrane Protein 1 Limp1 Melanoma-Associated Antigen Me491 Oma81h Ocular Melanoma-Associated Antigen Tetraspanin-30 Tspan-30 Cd Antigen Cd63 |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Lysosome Membrane Late Endosome Membrane Endosome Multivesicular Body Melanosome Secreted Extracellular Exosome Cell Surface Also Found In Weibel-Palade Bodies Of Endothelial Cells Located In Platelet Dense Granules Detected In A Subset Of Pre-Melanosomes Detected On Intralumenal Vesicles (Ilvs) Within Multivesicular Bodies |
| Alternative Antibody Names | Anti-Cd63 Antigen antibody Anti-Granulophysin antibody Anti-Lysosomal-Associated Membrane Protein 3 antibody Anti-Lamp-3 antibody Anti-Lysosome Integral Membrane Protein 1 antibody Anti-Limp1 antibody Anti-Melanoma-Associated Antigen Me491 antibody Anti-Oma81h antibody Anti-Ocular Melanoma-Associated Antigen antibody Anti-Tetraspanin-30 antibody Anti-Tspan-30 antibody Anti-Cd Antigen Cd63 antibody Anti-CD63 antibody Anti-MLA1 antibody Anti-TSPAN30 antibody |
Information sourced from Uniprot.org