| Tissue Specificity | Expressed predominantly in thymus, lymph node and spleen. |
| Post Translational Modifications | After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues. Phosphorylated on tyrosine residues in response to stimulation of the TCR complex. Glycosylated. |
| Function | Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule.promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS. |
| Protein Name | T-Cell Differentiation Antigen Cd6Cd Antigen Cd6 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinDetected At The Immunological SynapseIEAt The Contact Zone Between Antigen-Presenting Dendritic Cells And T-CellsColocalizes With The Tcr/Cd3 Complex At The Immunological Synapse |
| Alternative Antibody Names | Anti-T-Cell Differentiation Antigen Cd6 antibodyAnti-Cd Antigen Cd6 antibodyAnti-Cd6 antibody |
Information sourced from Uniprot.org
