| Tissue Specificity | Expressed in all tissues examined (liver, kidney, spleen, thymus, brain and heart). Low levels in thymus. Also expressed in mononuclear cells, erythrocytes and platelets. Barely detected in neutrophils. |
| Post Translational Modifications | N- and O-glycosylated. |
| Function | Potent inhibitor of the complement membrane attack complex (MAC) action, which protects self-cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. |
| Protein Name | Cd59a GlycoproteinMac-Inhibitory ProteinMac-IpMembrane Attack Complex Inhibition FactorMacifProtectinCd Antigen Cd59 |
| Database Links | |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedLocalizes To The Cell SurfaceSoluble Form Found In A Number Of Tissues |
| Alternative Antibody Names | Anti-Cd59a Glycoprotein antibodyAnti-Mac-Inhibitory Protein antibodyAnti-Mac-Ip antibodyAnti-Membrane Attack Complex Inhibition Factor antibodyAnti-Macif antibodyAnti-Protectin antibodyAnti-Cd Antigen Cd59 antibodyAnti-Cd59a antibodyAnti-Cd59 antibody |
Information sourced from Uniprot.org
