| Host: | Mouse |
| Applications: | FC/IF/IHC/ICC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal anti-CD59 for use in FC, IF, IHC, ICC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | 3C10 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Formulation: | Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. NA |
| Purification: | Lyophilized |
| Concentration: | Adding 0.2 mL of distilled water =f 500 Mu g/mL. |
| Storage Instruction: | Store at-20°C for up to 1 year. Minimise freeze-thaw cycles. |
| Gene Symbol: | CD59 |
| Gene ID: | 966 |
| Uniprot ID: | CD59_HUMAN |
| Immunogen: | E.coli-derived human CD59 recombinant protein (Position: L26-N102). Human CD59 shares 47.1% amino acid (aa) sequence identity with rat CD59. |
| Function | Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit complement membrane attack complex (MAC) assembly on cell membranes. |
| Protein Name | Cd59 Glycoprotein1f5 Antigen20 Kda Homologous Restriction FactorHrf-20Hrf20Mac-Inhibitory ProteinMac-IpMem43 AntigenMembrane Attack Complex Inhibition FactorMacifMembrane Inhibitor Of Reactive LysisMirlProtectinCd Antigen Cd59 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-6798695Reactome: R-HSA-6807878Reactome: R-HSA-977606 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedLocalizes To The Cell SurfaceSoluble Form Found In A Number Of Tissues |
| Alternative Antibody Names | Anti-Cd59 Glycoprotein antibodyAnti-1f5 Antigen antibodyAnti-20 Kda Homologous Restriction Factor antibodyAnti-Hrf-20 antibodyAnti-Hrf20 antibodyAnti-Mac-Inhibitory Protein antibodyAnti-Mac-Ip antibodyAnti-Mem43 Antigen antibodyAnti-Membrane Attack Complex Inhibition Factor antibodyAnti-Macif antibodyAnti-Membrane Inhibitor Of Reactive Lysis antibodyAnti-Mirl antibodyAnti-Protectin antibodyAnti-Cd Antigen Cd59 antibodyAnti-CD59 antibodyAnti-MIC11 antibodyAnti-MIN1 antibodyAnti-MIN2 antibodyAnti-MIN3 antibodyAnti-MSK21 antibody |
Information sourced from Uniprot.org
