• Human peripheral blood lymphocytes were stained with Anti-CD57 antibody (STJA0000391) (filled gray histogram). Unstained lymphocytes (empty black histogram) were used as control.

Anti-CD57/B3GAT1 antibody [HNK-1] {APC} (STJA0000391)

SKU:
STJA0000391

£144.50 - £306.50
Current Stock:
Host: Mouse
Applications: FC
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: HNK-1
Conjugation: APC
Isotype: IgMk
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: B3GAT1
Gene ID: 27087
Uniprot ID: B3GA1_HUMAN
Tissue Specificity Mainly expressed in the brain.
Post Translational Modifications The soluble form derives from the membrane form by proteolytic processing.
Function Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.
Protein Name Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 1
Beta-1 -3-Glucuronyltransferase 1
Glucuronosyltransferase P
Glcat-P
Udp-Glcua -Glycoprotein Beta-1 -3-Glucuronyltransferase
Glcuat-P
Database Links Reactome: R-HSA-1971475
Cellular Localisation Isoform 1: Golgi Apparatus Membrane
Single-Pass Type Ii Membrane Protein
Secreted
Isoform 2: Golgi Apparatus Membrane
Endoplasmic Reticulum Membrane
Alternative Antibody Names Anti-Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 1 antibody
Anti-Beta-1 -3-Glucuronyltransferase 1 antibody
Anti-Glucuronosyltransferase P antibody
Anti-Glcat-P antibody
Anti-Udp-Glcua -Glycoprotein Beta-1 -3-Glucuronyltransferase antibody
Anti-Glcuat-P antibody
Anti-B3GAT1 antibody
Anti-GLCATP antibody

Information sourced from Uniprot.org

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