Anti-CD5/Ly-1 antibody [SAA2084] (STJA0021870)

Anti-CD5/Ly-1 antibody [SAA2084] (STJA0021870)

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STJA0021870
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Short Description :Human monoclonal T-Cell Surface Glycoprotein Cd5 antibody for use in ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications:ELISA
Host:Human
Reactivity:Mouse
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Clonality :Monoclonal
Clone ID :SAA2084
Isotype:VHH-hFc
Conjugation:Unconjugated
Concentration:1 mg/mL
Purification:Protein A/G purified from cell culture supernatant
Formulation:0.01M PBS, pH 7.4.
Storage Instruction:Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months
Gene Symbol:Cd5
Gene ID:12507
Uniprot ID:CD5_MOUSE
Function Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation. Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production.
Protein Name T-Cell Surface Glycoprotein Cd5
Lymphocyte Antigen 1
Ly-1
Lyt-1
Cd Antigen Cd5
Database Links
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-T-Cell Surface Glycoprotein Cd5 antibody
Anti-Lymphocyte Antigen 1 antibody
Anti-Ly-1 antibody
Anti-Lyt-1 antibody
Anti-Cd Antigen Cd5 antibody
Anti-Cd5 antibody
Anti-Ly-1 antibody

Information sourced from Uniprot.org

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