![Anti-CD5 antibody [UCHT2] {PE/Cyanine5} (STJA0001425)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/147209/292736/STJA0001425_1__58767.1631206655.jpg?c=1 "Anti-CD5 antibody [UCHT2] {PE/Cyanine5} (STJA0001425)")
![Anti-CD5 antibody [UCHT2] {PE/Cyanine5} (STJA0001425)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/147209/292736/STJA0001425_1__58767.1631206655.jpg?c=1 "Anti-CD5 antibody [UCHT2] {PE/Cyanine5} (STJA0001425)")
Anti-CD5 antibody [UCHT2] {PE/Cyanine5} (STJA0001425)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationPE/Cyanine5
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal anti-T-cell surface glycoprotein CD5 for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | UCHT2 |
| Isotype | IgG1k |
| Conjugation | PE/Cyanine5 |
| Concentration | 5 Mu L/Test |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | CD5 |
| Gene ID | 921 |
| Uniprot ID | CD5_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylated on serine, threonine and tyrosine residues following TCR stimulation. Phosphorylated by LCK on Tyr-453 and Tyr-487 upon TCR engagement. |
| Function | Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation. Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production. |
| Protein Name | T-Cell Surface Glycoprotein Cd5Lymphocyte Antigen T1/Leu-1Cd Antigen Cd5 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Cell Surface Glycoprotein Cd5 antibodyAnti-Lymphocyte Antigen T1/Leu-1 antibodyAnti-Cd Antigen Cd5 antibodyAnti-CD5 antibodyAnti-LEU1 antibody |
Information sourced from Uniprot.org