Anti-CD5 antibody [Cris-1] (STJ16102737)

SKU:
STJ16102737-100
£387.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: Mouse
Applications: FC/IHC-F/IF/IP
Reactivity: Human/Rhesus Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal anti-CD5 for use in FC, IHC-F, IF and IP in Human and Rhesus Monkey samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : Cris-1
Conjugation: Unconjugated
Isotype: IgG2ak
Formulation: PBS with 0.02% sodium azide
Concentration: 100 Mu g/mL
Storage Instruction: Store at 2-8°C for up to 1-year, upon receipt.
Gene Symbol: CD5
Gene ID: 921
Uniprot ID: CD5_HUMAN
Immunogen: stimulated human leukocytes
Function Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation. Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production.
Protein Name T-Cell Surface Glycoprotein Cd5
Lymphocyte Antigen T1/Leu-1
Cd Antigen Cd5
Database Links
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-T-Cell Surface Glycoprotein Cd5 antibody
Anti-Lymphocyte Antigen T1/Leu-1 antibody
Anti-Cd Antigen Cd5 antibody
Anti-CD5 antibody
Anti-LEU1 antibody

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJ16101110 Anti-CD5 antibody [Cris-1] (STJ16101110) Mouse Monoclonal Human/Rhesus FC/IF/IHC/IP
STJA0021871 Anti-CD5/Ly-1 antibody [SAA2085] (STJA0021871) Human Monoclonal Mouse ELISA
STJA0021870 Anti-CD5/Ly-1 antibody [SAA2084] (STJA0021870) Human Monoclonal Mouse ELISA
STJA0037758 Anti-CD5 antibody (STJA0037758) Rabbit Monoclonal Human IHC-P
STJA0021869 Anti-CD5/Ly-1 antibody [SAA2083] (STJA0021869) Human Monoclonal Mouse ELISA

Related Products

!