Anti-CD5 antibody [Cris-1] (STJ16101110)

SKU:
STJ16101110

£287.50 - £1,324.50
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Host: Mouse
Applications: FC/IF/IHC/IP
Reactivity: Human/Rhesus
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD5 is suitable for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry and Immunoprecipitation research applications.
Clonality: Monoclonal
Clone ID: Cris-1
Conjugation: Unconjugated
Isotype: IgG2ak
Formulation: PBS with 0.02% Sodium Azide.
Purification: Affinity purified from tissue culture.
Concentration: Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range: Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Immunofluorescence (0, 5-1, 0µg/ml). Immunohistology (1-2 µg/ml for 30-60 minutes at RT; for staining of formalin-fixed tissues no suitable antigen retrieval method is known to date). Immunoprec
Storage Instruction: Store for up to 1 year at 2-8°C upon receipt.
Gene Symbol: CD5
Gene ID: 921
Uniprot ID: CD5_HUMAN
Immunogen: A BALB/c mouse was immunized with stimulating human leukocytes. Fusion partner: NS-1.
Post Translational Modifications Phosphorylated on serine, threonine and tyrosine residues following TCR stimulation. Phosphorylated by LCK on Tyr-453 and Tyr-487 upon TCR engagement.
Function Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation. Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production.
Protein Name T-Cell Surface Glycoprotein Cd5
Lymphocyte Antigen T1/Leu-1
Cd Antigen Cd5
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-T-Cell Surface Glycoprotein Cd5 antibody
Anti-Lymphocyte Antigen T1/Leu-1 antibody
Anti-Cd Antigen Cd5 antibody
Anti-CD5 antibody
Anti-LEU1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance