• Anti-CD5 antibody [4C7] (STJ16101711)

Anti-CD5 antibody [4C7] (STJ16101711)

SKU:
STJ16101711-1

£1,256.50
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD5 is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: 4C7
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: Tissue culture supernatant with sodium azide
Concentration: >=76 mg/L
Dilution Range: IHC-P 1:100
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: CD5
Gene ID: 921
Uniprot ID: CD5_HUMAN
Immunogen: Recombinant prokaryotic fusion protein corresponding to the external domain of the human CD5 molecule.
Post Translational Modifications Phosphorylated on serine, threonine and tyrosine residues following TCR stimulation. Phosphorylated by LCK on Tyr-453 and Tyr-487 upon TCR engagement.
Function Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation. Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production.
Protein Name T-Cell Surface Glycoprotein Cd5
Lymphocyte Antigen T1/Leu-1
Cd Antigen Cd5
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-T-Cell Surface Glycoprotein Cd5 antibody
Anti-Lymphocyte Antigen T1/Leu-1 antibody
Anti-Cd Antigen Cd5 antibody
Anti-CD5 antibody
Anti-LEU1 antibody

Information sourced from Uniprot.org

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