| Host: |
Goat |
| Applications: |
WB/IHC-F/IHC-P |
| Reactivity: |
Human/Rat/Mouse/Monkey/Canine |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-T-cell surface glycoprotein CD5 (105-210aa) is suitable for use in Western Blot, Immunohistochemistry and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS, 20% Glycerol and 0.05% Sodium Azide. |
| Purification: |
This antibody is epitope-affinity purified from goat antiserum. |
| Concentration: |
3 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC-F 1:250-1:1000IHC-P 1:250-1:1000 |
| Storage Instruction: |
For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours. |
| Gene Symbol: |
CD5 |
| Gene ID: |
921 |
| Uniprot ID: |
CD5_HUMAN |
| Immunogen Region: |
105-210aa |
| Accession Number: |
ENSG00000110448 |
| Specificity: |
Detects endogenous levels of CD5 by Western blot. |
| Immunogen: |
Recombinant peptide derived from within residues 105-210 aa of human CD5 produced in E. coli. |
| Immunogen Sequence: |
QSSIICYGQLGSFSNCSHSR NDMCHSLGLTCLEPQKTTPP TTRPPPTTTPEPTAPPRLQL VAQSGGQHCAGVVEFYSGSL GGTISYEAQDKTQDLENFLC NNLQCG |
| Post Translational Modifications | Phosphorylated on serine, threonine and tyrosine residues following TCR stimulation. Phosphorylated by LCK on Tyr-453 and Tyr-487 upon TCR engagement. |
| Function | Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation. Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production. |
| Protein Name | T-Cell Surface Glycoprotein Cd5Lymphocyte Antigen T1/Leu-1Cd Antigen Cd5 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Cell Surface Glycoprotein Cd5 antibodyAnti-Lymphocyte Antigen T1/Leu-1 antibodyAnti-Cd Antigen Cd5 antibodyAnti-CD5 antibodyAnti-LEU1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Anti-CD5 antibody [4C7] (STJ16100338)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/149055/346673/STJ16100338_1__06361.1681998751.jpg?c=1 "Anti-CD5 antibody [4C7] (STJ16100338)")
![Anti-CD5 antibody [4C7] (STJ16101711)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/152217/347069/STJ16101711_1__65416.1681999329.jpg?c=1 "Anti-CD5 antibody [4C7] (STJ16101711)")
