Anti-CD49c/ITGA3 nanobody [SAA1303] (STJN000181)

Anti-CD49c/ITGA3 nanobody [SAA1303] (STJN000181)

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STJN000181
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Integrin Alpha-3 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1303
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: ITGA3
Gene ID: 3675
Uniprot ID: ITA3_HUMAN
Post Translational Modifications Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation.
Function Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. (Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression.
Protein Name Integrin Alpha-3
Cd49 Antigen-Like Family Member C
Frp-2
Galactoprotein B3
Gapb3
Vla-3 Subunit Alpha
Cd Antigen Cd49c Cleaved Into - Integrin Alpha-3 Heavy Chain - Integrin Alpha-3 Light Chain
Database Links Reactome: R-HSA-210991
Reactome: R-HSA-216083
Reactome: R-HSA-3000157
Reactome: R-HSA-8874081
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Lipid-Anchor
Cell Projection
Invadopodium Membrane
Filopodium Membrane
Enriched Preferentially At Invadopodia
Cell Membrane Protrusions That Correspond To Sites Of Cell Invasion
In A Collagen-Dependent Manner
Alternative Nanobody Names Anti-Integrin Alpha-3 nanobody
Anti-Cd49 Antigen-Like Family Member C nanobody
Anti-Frp-2 nanobody
Anti-Galactoprotein B3 nanobody
Anti-Gapb3 nanobody
Anti-Vla-3 Subunit Alpha nanobody
Anti-Cd Antigen Cd49c Cleaved Into - Integrin Alpha-3 Heavy Chain - Integrin Alpha-3 Light Chain nanobody
Anti-ITGA3 nanobody
Anti-MSK18 nanobody

Information sourced from Uniprot.org

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