Anti-CD49c/ITGA3 antibody [84H7] {APC} (STJA0029331)

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STJA0029331
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Host: Mouse
Applications: ELISA/FC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Integrin Alpha-3 is suitable for use in ELISA, Flow Cytometry and Western Blot research applications.
Clonality : Monoclonal
Clone ID : 84H7
Conjugation: APC
Isotype: IgG1k
Formulation: 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Purification: Purified
Concentration: 0.5 mg/mL
Storage Instruction: Store at 4°C for 12 months. Protect from light. Do not freeze.
Gene Symbol: ITGA3
Gene ID: 3675
Uniprot ID: ITA3_HUMAN
Post Translational Modifications Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation.
Function Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. (Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression.
Protein Name Integrin Alpha-3
Cd49 Antigen-Like Family Member C
Frp-2
Galactoprotein B3
Gapb3
Vla-3 Subunit Alpha
Cd Antigen Cd49c Cleaved Into - Integrin Alpha-3 Heavy Chain - Integrin Alpha-3 Light Chain
Database Links Reactome: R-HSA-210991
Reactome: R-HSA-216083
Reactome: R-HSA-3000157
Reactome: R-HSA-8874081
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Lipid-Anchor
Cell Projection
Invadopodium Membrane
Filopodium Membrane
Enriched Preferentially At Invadopodia
Cell Membrane Protrusions That Correspond To Sites Of Cell Invasion
In A Collagen-Dependent Manner
Alternative Antibody Names Anti-Integrin Alpha-3 antibody
Anti-Cd49 Antigen-Like Family Member C antibody
Anti-Frp-2 antibody
Anti-Galactoprotein B3 antibody
Anti-Gapb3 antibody
Anti-Vla-3 Subunit Alpha antibody
Anti-Cd Antigen Cd49c Cleaved Into - Integrin Alpha-3 Heavy Chain - Integrin Alpha-3 Light Chain antibody
Anti-ITGA3 antibody
Anti-MSK18 antibody

Information sourced from Uniprot.org

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