![Anti-CD47/MER6 nanobody [SAA1315] (STJN000261)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200874/413056/STJN000261-SDS-PAGE-1__79004.1749232566.jpg?c=1 "Anti-CD47/MER6 nanobody [SAA1315] (STJN000261)")
![Anti-CD47/MER6 nanobody [SAA1315] (STJN000261)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200874/413056/STJN000261-SDS-PAGE-1__79004.1749232566.jpg?c=1 "Anti-CD47/MER6 nanobody [SAA1315] (STJN000261)")
Anti-CD47/MER6 nanobody [SAA1315] (STJN000261)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Leukocyte Surface antigen Cd47 is suitable for use in ELISA and Flow Cytometry research applications. |
| Applications | ELISA/FC |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1315 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | CD47 |
| Gene ID | 961 |
| Uniprot ID | CD47_HUMAN |
Additional Info
| Function | Adhesive protein that mediates cell-to-cell interactions. Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins. Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation. Plays a role in modulating pulmonary endothelin EDN1 signaling. Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering. Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging. In response to THBS1, negatively modulates wound healing. Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. |
| Protein Name | Leukocyte Surface Antigen Cd47Antigenic Surface Determinant Protein Oa3Integrin-Associated ProteinIapProtein Mer6Cd Antigen Cd47 |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-391160Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Nanobody Names | Anti-Leukocyte Surface Antigen Cd47 nanobodyAnti-Antigenic Surface Determinant Protein Oa3 nanobodyAnti-Integrin-Associated Protein nanobodyAnti-Iap nanobodyAnti-Protein Mer6 nanobodyAnti-Cd Antigen Cd47 nanobodyAnti-CD47 nanobodyAnti-MER6 nanobody |
Information sourced from Uniprot.org