| Post Translational Modifications | Heavily N- and O-glycosylated. |
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase CLeukocyte Common AntigenL-CaLymphocyte Antigen 5Ly-5T200Cd Antigen Cd45 |
| Database Links | Reactome: R-MMU-202427Reactome: -MMU-416700Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftSynapseColocalized With Dpp4 In Membrane Rafts |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase C antibodyAnti-Leukocyte Common Antigen antibodyAnti-L-Ca antibodyAnti-Lymphocyte Antigen 5 antibodyAnti-Ly-5 antibodyAnti-T200 antibodyAnti-Cd Antigen Cd45 antibodyAnti-Ptprc antibodyAnti-Ly-5 antibody |
Information sourced from Uniprot.org
![C57BL/6 murine splenocytes were stained with Anti-CD45 antibody (STJA0000864) [Used at 0.02 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained splenocytes (empty black histogram) were used as control.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/145717/292375/STJA0000864_1__10273.1631206232.jpg?c=1 "C57BL/6 murine splenocytes were stained with Anti-CD45 antibody (STJA0000864) [Used at 0.02 µg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained splenocytes (empty black histogram) were used as control.")
