Anti-CD44 antibody [SRM14753] (STJ11109483)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal CD44 antibody for use in WB, IF, ICC, FC and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/FC/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM14753 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB, 1:1000-1:2000IF/ICC, 1:200-1:800FC, 1:500-1:1000ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Cd44 |
| Gene ID | 12505 |
| Uniprot ID | CD44_MOUSE |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Tissue Specificity | Expressed in the intestinal epithelium. |
| Post Translational Modifications | N-glycosylated. O-glycosylated.contains chondroitin sulfate glycans which can be more or less sulfated. Phosphorylated.activation of PKC results in the dephosphorylation of Ser-742 (constitutive phosphorylation site), and the phosphorylation of Ser-708. |
| Function | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. |
| Protein Name | Cd44 AntigenExtracellular Matrix Receptor IiiEcmr-IiiGp90 Lymphocyte Homing/Adhesion ReceptorHutch-IHermes AntigenHyaluronate ReceptorLymphocyte Antigen 24Ly-24Phagocytic Glycoprotein 1Pgp-1Phagocytic Glycoprotein IPgp-ICd Antigen Cd44 |
| Database Links | Reactome: R-MMU-1474228Reactome: -MMU-202733Reactome: -MMU-216083Reactome: -MMU-2160916Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionMicrovillusSecretedColocalizes With Actin In Membrane Protrusionfs At Wounding EdgesCo-Localizes With RdxEzr And Msn In Microvilli |
| Alternative Antibody Names | Anti-Cd44 Antigen antibodyAnti-Extracellular Matrix Receptor Iii antibodyAnti-Ecmr-Iii antibodyAnti-Gp90 Lymphocyte Homing/Adhesion Receptor antibodyAnti-Hutch-I antibodyAnti-Hermes Antigen antibodyAnti-Hyaluronate Receptor antibodyAnti-Lymphocyte Antigen 24 antibodyAnti-Ly-24 antibodyAnti-Phagocytic Glycoprotein 1 antibodyAnti-Pgp-1 antibodyAnti-Phagocytic Glycoprotein I antibodyAnti-Pgp-I antibodyAnti-Cd Antigen Cd44 antibodyAnti-Cd44 antibodyAnti-Ly-24 antibody |
Information sourced from Uniprot.org