![Anti-CD41/Itga2b antibody [MWReg30] {APC} (STJA0002014)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/147798/292860/STJA0002014_1__27272.1631206865.jpg?c=1 "Anti-CD41/Itga2b antibody [MWReg30] {APC} (STJA0002014)")
![Anti-CD41/Itga2b antibody [MWReg30] {APC} (STJA0002014)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/147798/292860/STJA0002014_1__27272.1631206865.jpg?c=1 "Anti-CD41/Itga2b antibody [MWReg30] {APC} (STJA0002014)")
| Host: | Rat |
| Applications: | FC |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Rat monoclonal antibody anti-Integrin alpha-IIb is suitable for use in Flow Cytometry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | MWReg30 |
| Conjugation: | APC |
| Isotype: | IgG1k |
| Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Concentration: | 5 Mu L/Test |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
| Gene Symbol: | Itga2b |
| Gene ID: | 16399 |
| Uniprot ID: | ITA2B_MOUSE |
| Post Translational Modifications | Integrin alpha-IIb heavy chain: Cleaved by ELANE.the cleavage promotes activation of platelet fibrinogen receptor integrin alpha-IIb/beta-3. |
| Function | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
| Protein Name | Integrin Alpha-Iib Gpalpha Iib Gpiib Platelet Membrane Glycoprotein Iib Cd Antigen Cd41 Cleaved Into - Integrin Alpha-Iib Heavy Chain - Integrin Alpha-Iib Light Chain |
| Database Links | Reactome: R-MMU-114608 Reactome: -MMU-216083 Reactome: -MMU-3000178 Reactome: -MMU-354192 Reactome: -MMU-354194 Reactome: -MMU-372708 Reactome: -MMU-445144 Reactome: -MMU-5674135 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-Iib antibody Anti-Gpalpha Iib antibody Anti-Gpiib antibody Anti-Platelet Membrane Glycoprotein Iib antibody Anti-Cd Antigen Cd41 Cleaved Into - Integrin Alpha-Iib Heavy Chain - Integrin Alpha-Iib Light Chain antibody Anti-Itga2b antibody |
Information sourced from Uniprot.org