Anti-CD38 antibody (43-300) (STJ115571)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CD38 (43-300) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:2000-1:4000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CD38 |
| Gene ID | 952 |
| Uniprot ID | CD38_HUMAN |
| Immunogen Region | 43-300 |
| Immunogen Sequence | VPRWRQQWSGPGTTKRFPET VLARCVKYTEIHPEMRHVDC QSVWDAFKGAFISKHPCNIT EEDYQPLMKLGTQTVPCNKI LLWSRIKDLAHQFTQVQRDM FTLEDTLLGYLADDLTWCGE FNTSKINYQSCPDWRKDCSN NPVSVFWKTVSRRFAEAACD VVHVMLNGSRSKIFDKNSTF GSVEVHNLQPEKVQTLEAWV IHGGREDSRDLCQDPTIKEL ESIISKRNIQFSCKNIYRP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 43-300 of human CD38 (NP_001766.2). |
Additional Info
| Tissue Specificity | Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. |
| Function | Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity. |
| Protein Name | Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 12'-Phospho-Adp-Ribosyl Cyclase2'-Phospho-Adp-Ribosyl Cyclase/2'-Phospho-Cyclic-Adp-Ribose Transferase2'-Phospho-Cyclic-Adp-Ribose TransferaseAdp-Ribosyl Cyclase 1Adprc 1Cyclic Adp-Ribose Hydrolase 1Cadpr Hydrolase 1T10Cd Antigen Cd38 |
| Database Links | Reactome: R-HSA-196807 |
| Cellular Localisation | Cell SurfaceMembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1 antibodyAnti-2'-Phospho-Adp-Ribosyl Cyclase antibodyAnti-2'-Phospho-Adp-Ribosyl Cyclase/2'-Phospho-Cyclic-Adp-Ribose Transferase antibodyAnti-2'-Phospho-Cyclic-Adp-Ribose Transferase antibodyAnti-Adp-Ribosyl Cyclase 1 antibodyAnti-Adprc 1 antibodyAnti-Cyclic Adp-Ribose Hydrolase 1 antibodyAnti-Cadpr Hydrolase 1 antibodyAnti-T10 antibodyAnti-Cd Antigen Cd38 antibodyAnti-CD38 antibody |
Information sourced from Uniprot.org