Anti-CD369/CLEC7A antibody [15E2#] {PerCP} (STJA0030704)

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STJA0030704
£292.50 - £440.50
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Host: Mouse
Applications: FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-C-Type Lectin Domain Family 7 Member A is suitable for use in Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : 15E2#
Conjugation: PerCP
Isotype: IgG1k
Formulation: 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Purification: Purified
Concentration: 0.5 mg/mL
Storage Instruction: Store at 4°C for 12 months. Protect from light. Do not freeze.
Gene Symbol: CLEC7A
Gene ID: 64581
Uniprot ID: CLC7A_HUMAN
Post Translational Modifications Phosphorylated on tyrosine residues in response to beta-glucan binding.
Function Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans.
Protein Name C-Type Lectin Domain Family 7 Member A
Beta-Glucan Receptor
C-Type Lectin Superfamily Member 12
Dendritic Cell-Associated C-Type Lectin 1
Dc-Associated C-Type Lectin 1
Dectin-1
Cd Antigen Cd369
Database Links Reactome: R-HSA-5607764
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Isoform 5: Cytoplasm
Isoform 6: Cytoplasm
Isoform 7: Cytoplasm
Alternative Antibody Names Anti-C-Type Lectin Domain Family 7 Member A antibody
Anti-Beta-Glucan Receptor antibody
Anti-C-Type Lectin Superfamily Member 12 antibody
Anti-Dendritic Cell-Associated C-Type Lectin 1 antibody
Anti-Dc-Associated C-Type Lectin 1 antibody
Anti-Dectin-1 antibody
Anti-Cd Antigen Cd369 antibody
Anti-CLEC7A antibody
Anti-BGR antibody
Anti-CLECSF12 antibody
Anti-DECTIN1 antibody
Anti-UNQ539 antibody
Anti-PRO1082 antibody

Information sourced from Uniprot.org