| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Epithelial Cell Adhesion Molecule is suitable for use in Flow Cytometry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 9C4 |
| Conjugation: | PE/Cyanine5 |
| Isotype: | IgG2bk |
| Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Concentration: | 5 Mu L/Test |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
| Gene Symbol: | EPCAM |
| Gene ID: | 4072 |
| Uniprot ID: | EPCAM_HUMAN |
| Tissue Specificity | Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma. |
| Post Translational Modifications | Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability. |
| Function | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. |
| Protein Name | Epithelial Cell Adhesion Molecule Ep-Cam Adenocarcinoma-Associated Antigen Cell Surface Glycoprotein Trop-1 Epithelial Cell Surface Antigen Epithelial Glycoprotein Egp Epithelial Glycoprotein 314 Egp314 Hegp314 Ks 1/4 Antigen Ksa Major Gastrointestinal Tumor-Associated Protein Ga733-2 Tumor-Associated Calcium Signal Transducer 1 Cd Antigen Cd326 |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Lateral Cell Membrane Single-Pass Type I Membrane Protein Cell Junction Tight Junction Colocalizes With Cldn7 At The Lateral Cell Membrane And Tight Junction |
| Alternative Antibody Names | Anti-Epithelial Cell Adhesion Molecule antibody Anti-Ep-Cam antibody Anti-Adenocarcinoma-Associated Antigen antibody Anti-Cell Surface Glycoprotein Trop-1 antibody Anti-Epithelial Cell Surface Antigen antibody Anti-Epithelial Glycoprotein antibody Anti-Egp antibody Anti-Epithelial Glycoprotein 314 antibody Anti-Egp314 antibody Anti-Hegp314 antibody Anti-Ks 1/4 Antigen antibody Anti-Ksa antibody Anti-Major Gastrointestinal Tumor-Associated Protein Ga733-2 antibody Anti-Tumor-Associated Calcium Signal Transducer 1 antibody Anti-Cd Antigen Cd326 antibody Anti-EPCAM antibody Anti-GA733-2 antibody Anti-M1S2 antibody Anti-M4S1 antibody Anti-MIC18 antibody Anti-TACSTD1 antibody Anti-TROP1 antibody |
Information sourced from Uniprot.org