Anti-CD321/F11R/JAM-A antibody [SAA1942] (STJA0020370)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Junctional Adhesion Molecule A antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1942 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | F11R |
| Gene ID | 50848 |
| Uniprot ID | JAM1_HUMAN |
Additional Info
| Post Translational Modifications | N-glycosylated. (Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions. |
| Function | Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. |
| Protein Name | Junctional Adhesion Molecule AJam-AJunctional Adhesion Molecule 1Jam-1Platelet F11 ReceptorPlatelet Adhesion Molecule 1Pam-1Cd Antigen Cd321 |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-2173791Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneSingle-Pass Type I Membrane ProteinLocalized At Tight Junctions Of Both Epithelial And Endothelial Cells |
| Alternative Antibody Names | Anti-Junctional Adhesion Molecule A antibodyAnti-Jam-A antibodyAnti-Junctional Adhesion Molecule 1 antibodyAnti-Jam-1 antibodyAnti-Platelet F11 Receptor antibodyAnti-Platelet Adhesion Molecule 1 antibodyAnti-Pam-1 antibodyAnti-Cd Antigen Cd321 antibodyAnti-F11R antibodyAnti-JAM1 antibodyAnti-JCAM antibodyAnti-UNQ264 antibodyAnti-PRO301 antibody |
Information sourced from Uniprot.org