Anti-CD304/NRP1/NRP2 antibody [YW681126] {FITC} (STJA0027923)

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STJA0027923
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Host: Rat
Applications: ELISA/FC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Short Description : Rat monoclonal antibody anti-CD304/NRP1/NRP2 is suitable for use in ELISA and Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : YW681126
Conjugation: FITC
Isotype: IgG1k
Formulation: 0.01M PBS, pH 7.4, 02% BSA, 0.05% Proclin 300
Purification: Purified
Concentration: 05 mg/mL
Storage Instruction: Store at 4°C for 12 months Protect from light Do not freeze
Gene Symbol: Nrp1
Gene ID: 18186
Uniprot ID: NRP1_MOUSE
Function Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR.
Protein Name Neuropilin-1
A5 Protein
Cd Antigen Cd304
Database Links Reactome: R-MMU-194306
Reactome: -MMU-399954
Reactome: -MMU-399955
Reactome: -MMU-399956
Reactome: -MMU-445144
Cellular Localisation Mitochondrion Membrane
Single-Pass Type I Membrane Protein
Cell Membrane
Cytoplasm
Alternative Antibody Names Anti-Neuropilin-1 antibody
Anti-A5 Protein antibody
Anti-Cd Antigen Cd304 antibody
Anti-Nrp1 antibody
Anti-Nrp antibody

Information sourced from Uniprot.org