| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CD2AP (250-300 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Cd2ap |
| Gene ID: |
12488 |
| Uniprot ID: |
CD2AP_MOUSE |
| Immunogen Region: |
250-300 aa |
| Specificity: |
Specific for CD2AP. |
| Immunogen: |
A synthetic peptide from aa region 250-300 of mouse CD2AP conjugated to an immunogenic carrier protein was used as the antigen. |
| Post Translational Modifications | Phosphorylated on tyrosine residues.probably by c-Abl, Fyn and c-Src. |
| Function | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. Plays a role in epithelial cell junctions formation. |
| Protein Name | Cd2-Associated ProteinMesenchyme-To-Epithelium Transition Protein With Sh3 Domains 1Mets-1 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionRuffleCell JunctionColocalizes With F-Actin And Bcar1/P130cas In Membrane RufflesLocated At Podocyte Slit Diaphragm Between Podocyte Foot ProcessesDuring Late Anaphase And TelophaseConcentrates In The Vicinity Of The Midzone Microtubules And In The Midbody In Late Telophase |
| Alternative Antibody Names | Anti-Cd2-Associated Protein antibodyAnti-Mesenchyme-To-Epithelium Transition Protein With Sh3 Domains 1 antibodyAnti-Mets-1 antibodyAnti-Cd2ap antibodyAnti-Mets1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
