![Anti-CD279/PDCD1/PD1 nanobody [SAA1280] (STJN000275)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200888/413070/STJN000275-SDS-PAGE-1__09622.1749232577.jpg?c=1 "Anti-CD279/PDCD1/PD1 nanobody [SAA1280] (STJN000275)")
![Anti-CD279/PDCD1/PD1 nanobody [SAA1280] (STJN000275)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200888/413070/STJN000275-SDS-PAGE-1__09622.1749232577.jpg?c=1 "Anti-CD279/PDCD1/PD1 nanobody [SAA1280] (STJN000275)")
Anti-CD279/PDCD1/PD1 nanobody [SAA1280] (STJN000275)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Programmed Cell Death Protein 1 is suitable for use in ELISA, Flow Cytometry and SPR research applications. |
| Applications | ELISA/FC/SPR |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1280 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | PDCD1 |
| Gene ID | 5133 |
| Uniprot ID | PDCD1_HUMAN |
Additional Info
| Function | Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy. |
| Protein Name | Programmed Cell Death Protein 1Protein Pd-1Hpd-1Cd Antigen Cd279 |
| Database Links | Reactome: R-HSA-389948Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Nanobody Names | Anti-Programmed Cell Death Protein 1 nanobodyAnti-Protein Pd-1 nanobodyAnti-Hpd-1 nanobodyAnti-Cd Antigen Cd279 nanobodyAnti-PDCD1 nanobodyAnti-PD1 nanobody |
Information sourced from Uniprot.org