Anti-CD262/TRAILR2 antibody {PE} (STJ11108732)

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STJ11108732
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Host: Rabbit
Applications: FC
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Conjugation: PE
Isotype: IgG
Formulation: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis) , pH 7.3.
Purification: Affinity purification
Dilution Range: FC, 5 Mu l per 10^6 cells in 100 Mu l volume
Storage Instruction: Store at 4°C for up to 1 year from the date of receipt. Do not freeze.
Gene Symbol: Tnfrsf10b
Gene ID: 21933
Uniprot ID: TR10B_MOUSE
Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Tissue Specificity Highly expressed in heart, lung and kidney.
Post Translational Modifications (Microbial infection) Glycosylated at Arg-293 by S.typhimurium protein Ssek3.
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 10b
Death Receptor 5
Mk
Cd Antigen Cd262
Database Links Reactome: R-MMU-202733
Reactome: -MMU-3371378
Reactome: -MMU-5218900
Reactome: -MMU-69416
Reactome: -MMU-75158
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Tumor Necrosis Factor Receptor Superfamily Member 10b antibody
Anti-Death Receptor 5 antibody
Anti-Mk antibody
Anti-Cd Antigen Cd262 antibody
Anti-Tnfrsf10b antibody
Anti-Dr5 antibody
Anti-Killer antibody

Information sourced from Uniprot.org

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