Anti-CD257/BAFF/TNFSF13B antibody [BlySmAb-1.1] {PerCP} (STJA0030687)
SPECIFICATIONS
ClonalityMonoclonal
HostHuman
ConjugationPerCP
IsotypeIgG1L
General Information
| Short Description | Human monoclonal Tumor Necrosis Factor Ligand Superfamily Member 13b antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Human |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | BlySmAb-1.1 |
| Isotype | IgG1L |
| Conjugation | PerCP |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | TNFSF13B |
| Gene ID | 10673 |
| Uniprot ID | TN13B_HUMAN |
Additional Info
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. N-glycosylated. |
| Function | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 13bB Lymphocyte StimulatorBlysB-Cell-Activating FactorBaffDendritic Cell-Derived Tnf-Like MoleculeTnf- And Apol-Related Leukocyte Expressed Ligand 1Tall-1Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5669034Reactome: R-HSA-5676594 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTumor Necrosis Factor Ligand Superfamily Member 13bSoluble Form: Secreted |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Ligand Superfamily Member 13b antibodyAnti-B Lymphocyte Stimulator antibodyAnti-Blys antibodyAnti-B-Cell-Activating Factor antibodyAnti-Baff antibodyAnti-Dendritic Cell-Derived Tnf-Like Molecule antibodyAnti-Tnf- And Apol-Related Leukocyte Expressed Ligand 1 antibodyAnti-Tall-1 antibodyAnti-Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form antibodyAnti-TNFSF13B antibodyAnti-BAFF antibodyAnti-BLYS antibodyAnti-TALL1 antibodyAnti-TNFSF20 antibodyAnti-ZTNF4 antibodyAnti-UNQ401 antibodyAnti-PRO738 antibody |
Information sourced from Uniprot.org