| Background | Cluster of Differentiation 25 (CD25) is the extracellular region of the interleukin-2 receptor on activated B-and T-cells, myeloid precursors, and some other types of leukocytes. Since CD25 staining is useful for differentiating neoplastic mast cell aggregates from reactive proliferations, Anti-CD25 has become a major criterion for Systemic Mastocytosis diagnoses. In the context of urticaria pigmentosa, CD25 staining is also used to recognize mast cells in skin biopsies. There is a greater proportion of CD25+ and FOXP3+ regulatory T-cells among cancer cells in tumour parenchyma and its periphery in recurrent cutaneous melanoma compared to non-recurrent melanoma. |
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